OMTKY3 Substitution

OMTKY3 wild-type sequence diagram
P6 P5 P4 P2 P1 P1' P2' P3' P14' P18'
TYR (Y) GLY (G) ASN (N)

Note: in order to satisfy the additivity requirement described in the publications, either P2 must be THR or P1' must be GLU.

 
EnzymeDelta G ( kcal/mol )Delta G ( kJ/mol )Ka ( M-1 )Ki ( M )
VariantWild-typeDifferenceVariantWild-typeDifferenceVariantWild-typeRatioVariantWild-typeRatio
CHYM-15.23-15.230.00-63.72-63.720.001.9e+111.9e+111.0e+005.2e-125.2e-121.0e+00
PPE-14.34-14.340.00-60.00-60.000.004.2e+104.2e+101.0e+002.4e-112.4e-111.0e+00
CARL-14.22-14.220.00-59.50-59.500.003.4e+103.4e+101.0e+002.9e-112.9e-111.0e+00
SGPA-15.49-15.490.00-64.81-64.810.003.0e+113.0e+111.0e+003.4e-123.4e-121.0e+00
SGPB-14.51-14.510.00-60.71-60.710.005.6e+105.6e+101.0e+001.8e-111.8e-111.0e+00
HLE-13.21-13.210.00-55.27-55.270.006.1e+096.1e+091.0e+001.6e-101.6e-101.0e+00

OMTKY3 binding: sequence; distribution

This page was developed by Chris Bailey-Kellogg and ZhengPing Yi, using data from the lab of Michael Laskowski, Jr.

Please see the main page for source and citation information.

Last modified May 5, 2003.